Publications


Details are also available on Google Scholar.


Preprints

  1. Banerjee P, Kuhn J, Pal DS, Deng Y, Banerjee T, Devreotes PN and Iglesias PA. 2025. Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study. bioRxiv [preprint] 2025 Apr 14.  DOI:10.1101/2025.04.12.648264

  2. Abubaker-Sharif B, Devreotes PN, Iglesias PA. 2024. Machine learning sparse reaction-diffusion models from stochastic dynamics and spatiotemporal patterns, bioRxiv [preprint]. DOI: 10.1101/2024.10.02.616367.

  3. Deng Y, Banerjee T, Pal DS, Banerjee P, Zhan H, Borleis J, Iglesias PA, Devreotes PN. 2024. PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration, bioRxiv [preprint]. DOI: 10.1101/2024.09.15.613115.

  4. Kuhn J, Banerjee P, Haye A, Robinson DN, Iglesias PA, and Devreotes PN. 2024. Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity. bioRxiv [Preprint]. DOI: 10.1101/2024.02.13.580131.

  5. Lin Y, Parajón E, Yuan Q, Ye S, Qin G, Deng Y, Borleis J, Koyfman A, Iglesias PA, Konstantopolous K, Robinson DN and Devreotes PN. 2025. Dynamic and biphasic regulation of cell migration by Ras. bioRxiv [preprint] 2025 Feb 16. DOI:10.1101/2025.02.13.638204

Journal Articles

  1. Zhan H, Pal DS, Borleis J, Deng Y, Long Y, Janetopoulos C, Huang CH and Devreotes PN. Self-organizing glycolytic waves tune cellular metabolic states and fuel cancer progression. Nat Commun. 2025 Jul 1;16(1):5563. DOI:10.1038/s41467-025-60596-6

  2. Artemenko Y, Niu G, Arnold ME, Roberts KE, Fernandez BN, Flores T, McClave HD, Paestella M, Borleis J, Devreotes PN. 2024. A negative feedback loop between small GTPase Rap1 and mammalian tumor suppressor homolog KrsB regulates cell-substrate adhesion in Dictyostelium, Mol Biol Cell. 36(4):mbc.E24-11-0507. PMC12005108. DOI: 10.1091/mbc.E24-11-0507

  3. Lin Y*, Pal DS*, Banerjee P, Banerjee T, Qin G, Deng Y, Borleis J, Iglesias PA and Devreotes PN. 2024. Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration. Nat Cell Biol. 26(7):1062-1076. DOI: 10.1038/s41556-024-01453-4. Instagram: jhm.fundamentals

  4. Huang C-H, Albeck J, and Devreotes PN. 2024. Editorial: Self-organizing and excitable signaling networks in cell biology. Front. Cell Dev. Biol., 12:1430911. DOI: 10.3389/fcell.2024.1430911.

  5. Zhou Q, Jiao Z, Liu Y, Devreotes PN and Zhang Z. 2023. The effects of statins in patients with advanced-stage cancers - A systematic review and meta-analysis. Front Oncol.; 13:1234713. DOI: 10.3389/fonc.2023.1234713.

  6. Pal DS, Lin Y, Zhan H, Banerjee T, Kuhn J, Providence S and Devreotes PN. 2023. Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement. Front Cell Dev Biol 11:1195806. DOI: 10.3389/fcell.2023.1195806.

  7. Banerjee T, Matsuoka S, Biswas D, Miao Y, Pal DS, Kamimura Y, Ueda M, Devreotes PN, and Iglesias PA. 2023. A dynamic partitioning mechanism polarizes membrane protein distribution. Nat Commun. 14:7909. DOI: 10.1038/s41467-023-43615-2. WSE News: JHU Whiting School of Engineering News, JHU Engineering Magazine.

  8. Pal DS, Banerjee T, Lin Y, de Trogoff F, Borleis J, Iglesias PA, Devreotes PN. 2023. Actuation of single downstream nodes in growth factor network steers immune cell migration. Dev Cell 58(13):1170-1188.e7. DOI: 10.1016/j.devcel.2023.04.019 Press-release: Johns Hopkins Medicine News. Instagram: jhm.fundamentals

  9. Yang Q, Miao Y, Banerjee P, Hourwitz MJ, Hu M, Qing Q, Iglesias PA, Fourkas JG, and Losert W, and Devreotes PN 2022. Nanotopography modulates intracellular excitable systems through cytoskeleton actuation. Proc. Natl. Acad. Sci. U.S.A. 120(19): e2218906120 DOI:10.1101/2022.06.09.495528.

  10. Banerjee T, Biswas D*, Pal DS*, Miao Y, Iglesias PA, and Devreotes PN. 2022. Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration. Nat Cell Biol. 24, 1499–1515 (2022). DOI: 10.1101/2022.05.19.492577. Press-release: Johns Hopkins Medicine News. Instagram: jhm.fundamentals.

  11. Yang Q, Miao Y, Campanello LJ, Hourwitz MJ, Bull AL, Devreotes PN, Fourkas JT, and Losert W. 2022. Cortical waves mediate the cellular response to electric fields. eLife. 11:e73198. DOI: 10.7554/eLife.73198.

  12. Ghabache E, Cao Y, Miao Y, Groisman A, Devreotes PN, and Rappel W-J. 2021. Coupling traction force patterns and actomyosin wave dynamics reveals mechanics of cell motion. Mol Sys Biol. 17:e10505. DOI: 10.15252/msb.202110505.

  13. Kuhn J, Lin Y, and Devreotes PN. 2021. Using live-cell imaging and synthetic biology to probe directed migration in Dictyostelium. Front. Cell Dev Biol. 9:740205. DOI: 10.3389/fcell.2021.740205.

  14. Biswas D, Devreotes PN, and Iglesias PA. 2021. Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells. PLoS Comput Biol. 17(7):e1008803. DOI: 10.1371/journal.pcbi.1008803.

  15. Kim JH, Hanlon CD, Vohra S, Devreotes PN, and Andrew DJ. 2021. Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P2 to direct migration of Drosophila embryonic germ cells. Cell Rep. 34(9):108799. DOI: 10.1016/j.celrep.2021.108799.

  16. Song B, Gu Y, Jiang W, Li Y, Ayre WN, Liu Z, Yin T, Janetopolous C, Iijima M, Devreotes PN, and Zhao M. 2021. Electric Signals Counterbalanced Posterior vs Anterior PTEN Signaling in Directed Migration of Dictyostelium. Cell Biosci. 11(1):111 DOI: 10.1186/s13578-021-00580-x.

  17. Li X, Pal DS, Biswas D, Iglesias PA, and Devreotes PN. 2021. Reverse fountain flow of phosphatidylinositol-3,4-biphosphate polarizes migrating cells. EMBO J. 40(4):e105094. DOI: 10.15252/embj.2020105094.

  18. Bhattacharya S, Banerjee T, Miao Y, Zhan H, Devreotes PN, and Iglesias PA. 2020. Traveling and standing waves mediate pattern formation in cellular protrusions. Science Advances. 6(32):eaay 7682. DOI: 10.1126/sciadv.aay7682.

  19. Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang C-H, and Devreotes PN. 2020. An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Dev Cell. 54(5):608-623.e5. DOI: 10.1016/j.devcel.2020.08.001.

  20. Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, Ewald AJ, and Devreotes PN. 2020. Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. Proc Natl Acad Sci U S A. 117(8): 4158-4168. DOI: 10.1073/pnas.1917938117.

  21. Li X, Miao Y, Pal DS, and Devreotes PN. 2020. Excitable networks controlling cell migration during development and disease. Semin Cell Dev Biol. 100:133-142. DOI: 10.1016/ j.semcdb.2019.11.001.

  22. Devreotes PN. 2019. Moving toward molecular mechanisms for chemotaxis in eukaryotic cells. Mol Biol Cell. 30(23):2873-77. DOI: 10.1091/mbc.E19-07-0393.

  23. Cao Y, Ghabache E, Miao Y, Niman C, Hakozaki H, Reck-Peterson SL, Devreotes PN, and Rappel W-J. 2019. A minimal computational model for three-dimensional cell migration. J R Soc Interface. 16(161): 20190619. DOI: 10.1098/rsif.2019.0619.

  24. Pal DS, Li X, Banerjee T, Miao Y, and Devreotes PN. 2019. The Excitable Signal Transduction Networks: Movers and Shapers of Eukaryotic Cell Migration. Int J Dev Biol. 63 (8-9-10): 407-416. DOI: 10.1387/ijdb.190265pd.

  25. Miao Y, Battacharya S, Banerjee T, Abudaker-Sharif B, Long Y, Inoue T, Iglesias P, and Devreotes PN. 2019. Wave patterns organize cellular protrusions and control cortical dynamics. Mol. Syst. Biol 15(3):e8585. DOI: 10.15252/msb.20188585.

  26. Miyanaga Y, Kamimura Y, Kuwayama H, Devreotes PN, and Ueda M. 2018. Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis. Biochem. Biophys. Res. Commun.. 507(1-4): 304-310. DOI: 10.1016/j.bbrc.2018.11.029.

  27. Neumann NM, Perrone MC, Veldhuis JH, Huebner RJ, Zhan H, Devreotes PN, Brodland GW, and Ewald AJ. 2018. Coordination of receptor tyrosine kinase signaling and interfacial tension dynamics drive radial intercalation and tube elongation. Dev. Cell 45(1):67-82.e6. DOI: 10.1016/j.devcel.2018.03.11.

  28. Li X*, Edwards M*, Swaney KF, Singh N, Bhattacharya S, Borleis J, Long Y, Iglesias PA, Chen J, and Devreotes PN. 2018. Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration. Proc Natl Acad Sci U S A. 115(39), E9125-E9134. DOI: 10.1073/pnas.1809039115.

  29. Edwards M, Cai H, Abubaker-Sharif B, Long Y, Lampert T, and Devreotes PN. 2018. Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum. Proc Natl Acad Sci U S A. 115(16):E3722-E3730. DOI: 10.1073/pnas.1710480115.

  30. Schiapparelli P, Guerrero-Cazares H, Magaña-Maldonado R, Hamilla SM, Ganaha S, Goulin Lippi Fernandes E, Huang CH, Aranda-Espinoza H, Devreotes PN, Quinones-Hinojosa A. 2017. NKCC1 regulates migration ability of glioblastoma cells by modulation of actin dynamics and interacting with Cofilin. EBioMedicine 21:94-103. DOI: 10.1016/j.ebiom.2017.06.020.

  31. Devreotes PN, Bhattacharya S, Edwards M, Iglesias PA, Lampert T, Miao Y. 2017. Excitable Signal Transduction Networks in Directed Cell Migration. Annu Rev Cell Dev Biol 33:103-125. DOI: 10.1146/annurev-cellbio-100616-060739.

  32. Artemenko, Y, Devreotes, PN. 2017. Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation. J. Vis. Exp.129, 56411. DOI: 10.3791/56411.

  33. Lampert TJ, Kamprad N, Edwards M, Borleis J, Watson AJ, Tarantola M, Devreotes PN. 2017. Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity. Proc Natl Acad Sci USA 114(37) E7727-E7736. DOI: 10.1073/pnas.1616600114.

  34. Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes PN, Wolberger C, Amzel M, Gabelli SB, Cole PA. 2017. A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell 66(3): 345-357. DOI: 10.1016/j.molcel.2017.03.020.

  35. Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias P, Devreotes PN. 2017. Altering the threshold of an excitable signal transduction network changes cell migratory mode. Nat Cell Biol 19(4):329-340. DOI: 10.1038/ncb3495.

  36. Artemenko Y, Axiotakis L Jr., Borleis J, Iglesias PA, Devreotes PN. 2016. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proc Natl Acad Sci U S A 113(47):E7500-E7509. DOI: 10.1073/pnas.1608767113.

  37. Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, and Weiner OD. 2016. Gβ regulates coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLoS Biol Feb. 18; 14(2):e1002381. PMCID: PMC4758609. DOI:10.1371/journal.pbio.1002381

  38. Huang C-H and Devreotes PN. 2015. Reaction diffusion waves of phosphoinositides in the membrane. ASBMB TODAY September 2015 - Lipid News. https://www.asbmb.org/asbmb-today/science/090115/reaction-diffusion-waves-of-phosphoinositides

  39. Nguyen H-N, Yang J-M, Miyamoto T, Itoh K, Rho E, Zhang Q, Inoue T, Devreotes PN, Sesaki H, and Iijima M. 2015. Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN. Sci Rep Jul 28;5:12600. DOI: 10.1038/srep12600. PMCID: PMC4517176.

  40. Santhanam B, Cai H, Devreotes PN, Shaulsky G, and Katoh-Kurasawa M. 2015. The GATA transcription factor GtaC regulates early developmental gene expression in Dictyostelium. Nat Commun. Jul 6;6:7551. DOI: 10.1038/ncomms8551. PMCID: PMC4506546.

  41. Gao R, Zhao S, Sun Y, Sanjun Zhao, Gao J, Borleis J, Willard S, Tang M, Cai H, Kamimura Y, Huang Y, Jiang J, Huang Z, Mogilner A, Pan T, Devreotes PN, Zhao M. 2015. A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium Discoideum. Sci Signal, May 26;8(378):ra50. PMCID:PMC4470479. DOI:10.1126/scisignal.aab0562

  42. Swaney KF, Borleis J, Iglesias PA and Devreotes PN. 2015. Novel protein Callipygian defines the back of migrating cells. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3845-54. PMCID: PMC4517219. DOI:10.1073/pnas.1509098112

  43. Yang JM, Nguyen HN, Sesaki H, Devreotes PN, and Iijima M. 2014. Engineering PTEN function: Membrane association and activity. Methods Oct 22. pii: S1046-2023(14)00335-1. PMCID: PMC4388803. DOI:10.1016/j.ymeth.2014.10.018

  44. Tang M, Wang M, Shi C, Iglesias PA, Devreotes PN, and Huang CH. 2014. Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. Nat Commun. Oct 27;5:5175. PMCID: PMC 4211273. DOI:10.1038/ncomms6175

  45. Wang M, Artemenko Y, Cai W, Iglesias PA, and Devreotes, PN. 2014. The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient. Cell Rep. Nov. 6; 9(3): 1110-1121. PMCID: PMC4250826. DOI:10.1016/j.celrep.2014.09.047

  46. Nguyen, H-N., Yang, J.M., Rahdar, M., Keniry, M., Swaney KF, Parsons, R., Park, B.H., Sesaki, H., Devreotes, P.N. and Iijima, M. 2014. A new class of cancer-associated PTEN mutations defined by membrane translocation defects. Oncogene Sept 29;0. PMCID: PMC4377315. DOI:10.1038/onc.2014.293

  47. Devreotes, P.N. and Horwitz, A.R. Signaling networks that regulate cell migration. In: Cantley, L.C., Hunter, T., Sever, R., Thorner, J. (Eds.). 2014. Signal Transduction. Principles, Pathways and Processes. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York: pp. 183-198.

  48. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, and Leslie NR. (2014) A unified nomenclature and amino acid numbering for human PTEN. Sci Signal July 1;7(332):pe15. PMCID: PMC4367864. DOI:10.1126/scisignal.2005560

  49. Nguyen HN, Yang JM, Afkari Y, Park BH, Sesaki H, Devreotes PN, and Iijima M. 2014. Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities. Proc Natl Acad Sci U S A. Jul 1;111(26):E2684-93. DOI: 10.1073/pnas.1409433111. Epub 2014 Jun 16. PMCID: PMC4084459. DOI:10.1073/pnas.1409433111

  50. Artemenko, Y., Lampert, T.J., Devreotes, P.N. 2014. Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci. Oct;71(19):3711-47. DOI: 10.1007/s00018-014-1638-8. Epub 2014 May 21. PMCID: PMC4162842. DOI:10.1007/s00018-014-1638-8

  51. Cai H., Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, and Devreotes PN. 2014. Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science. 21;343(6177):1249531. PMCID: PMC4061987. DOI:10.1126/science.1249531.

  52. Nguyen, H-N, Afkari, Y., Senoo, H., Sesaki, H., Devreotes, P.N., and Iijima, M. Mechanisms of human PTEN localization revealed by heterologous expression in Dictyostelium. 2014. Oncogene, Dec. 2. PMCID: PMC4041858. DOI:10.1038/onc.2013.507

  53. Huang, C.,Tang, M., Shi, C.,Iglesias, P., and Devreotes, P.N. An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nat Cell Biol. 2013 Nov;15(11):1307-16. PMCID: PMC3838899. DOI:10.1038/ncb2859

  54. Roppenser, B., Kwon, H., York, J.D., Snyder, S.H., Devreotes, P. N., Grinstein, S., and Brummel, J.H. 2013. Multiple host kinases contribute to Akt activation during Salmonella infection. PLoS One. 2013 Aug 22;8(8):e71015. PMCID: PMC3750030. DOI:10.1371/journal.pone.0071015

  55. Shi, C., Huang, C., Devreotes, P.N., and Iglesias, P. 2013. Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells., PLOS Computational Biol. 2013 Jul;9(7):e1003122. PMCID: PMC3701696. DOI:10.1371/journal.pcbi.1003122

  56. Artemenko Y and Devreotes PN. 2013. Hippo on the move: tumor suppressor regulates adhesion and migration. Cell Cycle Feb 15;12(4):535-6. DOI: 10.4161/cc.23668. Epub 2013 Jan 31. PMCID: PMC3594247. DOI:10.4161/cc.23668

  57. Bolduc, D.M., Rahdar, M., Tu-Sekine, B., Sivakumaren S.C., Raben, D.M., Amzel, L.M., Devreotes, P.N., Gabelli, S.B., Cole, P.A. Phosphorylation-mediated PTEN Conformational Closure and Deactivation Revealed with Protein Semisynthesis. Elife. 2013 Jul 9;2:e00691. PMCID: PMC3707082. DOI:10.7554/eLife.00691

  58. Zhao S, Gao R, Devreotes PN, Mogilner A, Zhao M. 2013. 3D Arrays for high throughput assay of cell migration and electrotaxis. Cell Biol Int. Sep;37(9):995-1002. DOI: 10.1002/cbin.10116. Epub 2013 May 7. PMCID: PMC3729600. DOI:10.1002/cbin.10116

  59. Artemenko, Y., Batsios, P., Borleis, J., Gagnon, Z., Lee, J., Rohlfs, M., Sanséau, D., Willard, S.S., Schleicher, M., and Devreotes, P.N. 2012. Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. PNAS 2012;109(34):13632-13637. PMCID: PMC3427065. DOI:10.1073/pnas.1211304109

  60. Galloway, J.F., Winter, A., Lee, K.H., Park, J., Dvoracek, C., Devreotes, P.N., and Searson, P.C. 2012. Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications. Nanomedicine 8:1190-1199. PMCID: PMC3320680. DOI:10.1016/j.nano.2011.12.002

  61. Iglesias, P.A. and Devreotes, P.N. 2012. Biased excitable networks: how cells direct motion in response to gradients. Curr. Opin. Cell Biol., 757:451-468. PMCID: PMC3415256. DOI:10.1016/j.ceb.2011.11.009

  62. Cai, H., Huang, C.H., Devreotes, P.N., and Iijima, M. 2012. Analysis of chemotaxis in Dictyostelium. Methods Mol Biol 757:451-468. PMCID: PMC3381519. DOI:10.1007/978-1-61779-166-6_26

  63. Iglesias, P.A. and Devreotes, P.N. 2012. Biased excitable networks: how cells direct motion in response to gradients. Curr. Opin. Cell Biol., 757:451-468. PMCID: PMC3415256. DOI:10.1016/j.ceb.2011.11.009

  64. Cai, H., and Devreotes, P.N. 2011 Moving in the right direction: How eukaryotic cells migrate along chemical gradients. Semin. Cell Dev. Biol. 22(8):834-841. PMCID:PMC4083813. DOI:10.1016/j.semcdb.2011.07.020

  65. Tang, M., Iijima, M., and Devreotes, P.N. 2011. Generation of cells that ignore the effects of PIP3 on cytoskeleton. Cell Cycle, 10:2817-2818. PMCID: PMC3218594. DOI:10.4161/cc.10.17.16744

  66. Gao, R.C., Zhang, X.D., Sun, Y.H., Kamimura,Y., Mogilner, A., Devreotes, P.N., and Zhao, M. 2011. Different roles of Membrane potentials in electrotaxis and chemotaxis of Dictyostelium Cells. Eukaryot Cell, 10:1251-1256. PMCID: PMC3187056. DOI: 10.4161/cc.10.17.16744

  67. Artemenko, Y., Swaney, K., and Devreotes, P.N. 2011. Assessment of development and chemotaxis in Dictyostelium discoideum mutants. Meth. Mol. Biol. 769:287-309. DOI:10.1007/978-1-61779-207-6_20

  68. de Keijzer, S., Galloway, J., Devreotes, P.N., and Iglesias, P.A. 2011. Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane. Biochimica et Biophysica Acta, 1808:1701-1708. PMCID: PMC3079046. DOI:10.1016/j.bbamem.2011.02.009

  69. Tang, M., Iijima, M., Kamimura, Y., Chen, L., Long, Y., and Devreotes, P.N. 2011. Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol. Biol. Cell. 22:437-447. PMCID: PMC3038642. DOI:10.1091/mbc.e10-06-0522

  70. QnAs with Peter N. Devreotes. 2010. Interview by Prashant Nair. PNAS, 107:19613. PMCID: PMC2993395. DOI:10.1073/pnas.1014645107

  71. Kamimura, Y., Cai, H., Tang, M., and Devreotes, P.N. 2010 TorC2 and chemotaxis in Dictyostelium discoideum. In: The Enzymes (Michael N. Hall and Fuyuhiko Tamanoi, eds.). Academic Press, Volume 28, pp. 125-142.

  72. Xiong, Y., Huang, C-H, Iglesias, P.A., and Devreotes, P.N. 2010. Cells navigate with a local-excitation, global-inhibition-biased excitable network. PNAS, 107:17079-17086. PMCID: PMC2951443. DOI:10.1073/pnas.1011271107

  73. Cai, H., Das, S., Kamimura, Y., Comer, F.I., Parent, D.A., and Devreotes, P.N. 2010. Ras-mediated activation and inactivation of the TorC2-PKB pathway are critical for chemotaxis. J. Cell Biol., 190:233-245. PMCID: PMC2930282. DOI:10.1083/jcb.201001129

  74. Xiong, Y., Kabacoff, C., Franca-Koh, J., Devreotes, P.N., Robinson, D.N., and Iglesias, P.A. 2010. Automated characterization of cell shape changes during amoeboid motility by skeletonization. BMC Syst. Biol., 4:33. PMCID: PMC2864235. DOI:10.1186/1752-0509-4-33

  75. Swaney, K.F., Huang, C.H., Devreotes, P.N. 2010. Eukaryotic Chemotaxis: A network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 278:20445-20448. PMID: 20192768. DOI:10.1146/annurev.biophys.093008.131228

  76. Kamimura, Y., and Devreotes, P.N. 2010. Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem 285(11):7938-7946. PMCID: PMC2832944. DOI:10.1074/jbc.m109.089235

  77. Franca-Koh, J., Willard, S.S., and Devreotes, P.N. 2009. G-Protein Signaling in Chemotaxis. In: Ralph A. Bradshaw and Edward A. Dennis, editors, Handbook of Cell Signaling 2nd edition. Oxford: Academic Press, pp. 1705-1712.

  78. Kamimura, Y., Tang, M., and Devreotes, P.N. 2009. Assays for Chemotaxis and Chemoattractant-Stimulated TorC2 Activation and PKB Substrate Phosphorylation in Dictyostelium. In: Chemotaxis, Methods in Molecular Biology, vol. 571. (T. Jin and D. Hereld, eds.). Humana Press.

  79. Rahdar, M., Inoue, T., Meyer T., Zhang, J., Vazquez, F., Devreotes, P.N. 2009. A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. PNAS 106:480-485. PMCID: PMC2626728. DOI:10.1073/pnas.0811212106

  80. Tang, L., Franca-Koh, J., Xiong, Y., Chen, M-Y., Long, Y., Bickford, R.M., Knecht, D.A., Iglesias, P.A., and Devreotes, P.N. 2008. Tsunami, the Dictyostelium homolog of the Fused kinase is required for polarization and chemotaxis. Genes Dev. 22:2278-2290. PMCID: PMC2518819. DOI:10.1101/gad.1694508

  81. Kamimura, Y., Xiong, Y., Iglesias, P.A., Hoeller, O., Bolourani, P. and Devreotes, P.N. 2008. PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Bio. July 22; 18(14):1034-43. PMCID: PMC4018231. DOI:10.1016/j.cub.2008.06.068

  82. Iglesias, P.A. and Devreotes, P.N. 2008. Navigating through models of chemotaxis. Curr. Opin. Cell Bio., 20(1):35-40. DOI:10.1016/j.ceb.2007.11.011

  83. Sasaki, A.T., Janetopoulos, C., Lee, S., Charest, P.G., Takeda, K., Sundheimer, L.W., Meili, R., Devreotes, P.N., and Firtel, R.A. 2007. G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J. Cell Bio. 178(2):185-191. DOI:10.1083/jcb.200611138

  84. Chen, L., Iijima, M., Tang, M., Landree, M.A., Huang, Y.E., Xiong, Y., Iglesias, P.A., and Devreotes, P.N. 2007. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev. Cell 12(4):603-614. DOI:10.1016/j.devcel.2007.03.005

  85. Franca-Koh, J., Kamimura, Y., Devreotes, P.N. 2007. Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nat. Cell Biol. 9:15-17. DOI:10.1038/ncb0107-15

  86. Somesh BP, Vlahou G, Iijima M, Insall RH, Devreotes P and Rivero-Crespo FR. 2006. RacG regulates morphology, phagocytosis and chemotaxis.  Eukaryot Cell. 2006 Oct;5(10):1648-63. DOI:10.1128/ec.00221-06

  87. Somesh, B.P., Neffgen, C., Iijima, M., Devreotes, P.N., and Rivero-Crespo, F.R. 2006. Dictyostelium RacH regulates endocytic vesicular trafficking and is required for localization of vacuolin. Traffic 7:1194-1212. DOI:10.1111/j.1600-0854.2006.00455.x

  88. Willard, S. and Devreotes, P.N. 2006. Signaling pathways mediating chemotaxis in the social amoebae, Dictyostelium discoideum. Eur. J. Cell Biol. 85:897-904. DOI:10.1016/j.ejcb.2006.06.003

  89. Janetopoulos, C. and Devreotes, P.N. 2006. Phosphoinositide signaling plays a key role in cytokinesis. Minireview. J. Cell Biol. 174:485-490. DOI:10.1083/jcb.200603156

  90. Zhao, M., Song, B., Pu, J., Wada, T., Reid, B., Tai, G., Wang, F., Guo, A., Walczysko, P., Sasaki, T., Suzuki, A., Forrester, J.V., Bourne, H.R., Devreotes, P.N., McCaig, C.D., and Penninger, J.M. 2006. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature 442:457-460. DOI:10.1038/nature04925

  91. Vazquez, F. and Devreotes, P.N. 2006. Regulation of PTEN function as PIP3 gatekeeper through membrane interaction. Cell Cycle 5:1523-1527. DOI:10.4161/cc.5.14.3005

  92. Franca-Koh, J., Kamimura, Y., Devreotes, P.N. 2006. Navigating signaling networks: chemotaxis in Dictyostelium discoideum. Curr. Opin. Genet. Dev.16:333-338. DOI:10.1016/j.gde.2006.06.001

  93. Loovers, H.M., Postma, M., Keizer-Gunnink, I., Huang, Y.E., Devreotes, P.N., and van Haastert, P.J.M. 2006. Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: A quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell 17:1503-1513. DOI:10.1091/mbc.e05-09-0825

  94. Vazquez, F., Matsuoka, S., Sellers, W.R., Yanagida, T., Ueda, M., and Devreotes, P.N. 2006. Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. PNAS 103:3633-3638. DOI:10.1073/pnas.0510570103

  95. Matsuoka, S., Iijima, M., Watanabe, T.M., Kuwayama, H., Yanagida, T., Devreotes, P.N., and Ueda, M. 2006. Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. J Cell Sci 119:1071-1079. DOI:10.1242/jcs.02824

  96. Fache, S., Dalous, J., Engelund, M., Hansen, C., Chamaraux, F., Fourcade, B., Satre, M., Devreotes, P., and Bruckert, F. 2005. Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility. J Cell Sci 118: 3445-3457. DOI:10.1242/jcs.02461

  97. Janetopoulos, C., Borleis, J., Vazquez, F., Iijima, M., and Devreotes, P.N. 2005. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev. Cell 8:467-477. DOI:10.1016/j.devcel.2005.02.010

  98. Janetopoulos, C., Long, Y., and Devreotes, P.N. 2005. Mechanisms of Eukaryotic Chemotaxis. In: Cell Migration in Development and Disease (D. Wedlich, ed.). Wiley-VCH Publications, Chapter 3, pp. 33-45.

  99. Ma, L., Janetopoulos, C., Yang, L., Devreotes, P.N., Iglesias, P.A. 2004. Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in Dictyostelium cells. Biophys J. 87:3764-74. DOI:10.1529/biophysj.104.045484

  100. Manahan, C.L., Iglesias, P.A., Long, Y., and Devreotes, P.N. 2004. Chemoattractant signaling in Dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20:223-253. DOI:10.1146/annurev.cellbio.20.011303.132633

  101. Franca-Koh, J. and Devreotes, P.N. 2004. Moving forward: mechanisms of chemoattractant gradient sensing. Physiology 19:300-308. DOI:10.1152/physiol.00017.2004

  102. Van Haastert, P.J. and Devreotes, P.N. 2004. Chemotaxis: signaling the way forward. Nat. Mol. Cell Biol. 5(8):626-634. DOI:10.1038/nrm1435

  103. Hynes, T.R., Tang, L., Mervine, S.M., Sabo, J.L., Yost, E.A., Devreotes, P.N., and Berlot, C.H. 2004. Visualization of G-protein βγ dimers using bimolecular fluorescence complementation demonstrates roles for both β and γ in subcellular targeting.  J Biol Chem. 2004;279(29):30279-30286. DOI:10.1074/jbc.m401432200

  104. Janetopoulos, C., Ma, L., Devreotes, P.N., and Iglesias, P.A. 2004. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. PNAS 101(24):8951-8956. DOI:10.1073/pnas.0402152101

  105. Montell, C. and Devreotes, P.N. 2004. Annual Review on Cell Regulation - From protein dynamics to animal behavior: new insights into complex cell regulatory mechanisms. Curr. Opin. Cell Biol. 16:115-118. DOI:10.1016/j.ceb.2004.02.011

  106. Hereld, D. and Devreotes, P.N. 2004. Cyclic AMP Receptors of Dictyostelium. Encyclopedia of Biological Chemistry. (W.J. Lennarz and M.D. Lane, eds.), Elsevier, Oxford, Vol.1, pp. 488-493.

  107. Iijima, M., Huang, Y.E., Luo, H.R., Vazquez, F., and Devreotes, P.N. 2004. Novel mechanism of PTEN regulation by its Phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J. Biol. Chem. 279(16):16606-16613. DOI:10.1074/jbc.m312098200

  108. Kutscher, B., Devreotes, P.N., and Iglesias, P.A. 2004. Local excitation, global inhibition mechanism for gradient sensing: An interactive applet. Sci STKE 219:13. DOI:10.1126/stke.2192004pl3

  109. Manahan, C.L. and Devreotes, P.N. 2003. βγ signaling in chemotaxis. In: Handbook of Cell Signaling (R. Bradshaw and E. Dennis, eds.). Academic Press, San Diego, CA, Vol. 2, Chapter 227, pp. 645-649.

  110. Chen, L., Janetopoulos, C., Huang, Y.E., Iijima, M., Borleis, J., and Devreotes, P.N. 2003. Two phases of actin polymerization display different dependences on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol. Biol. Cell 14(12):5028-5037. DOI:10.1091/mbc.e03-05-0339

  111. Luo, H.R., Huang, Y.E., Chen, J.C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P.N., and Snyder, S.H. 2003. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell 114(5), 559-572. DOI:10.1016/s0092-8674(03)00640-8

  112. Landree, M.A. and Devreotes, P.N. 2004. Analyzing chemotaxis using Dictyostelium discoideum as a model system. In: Cell Migration in Inflammation and Immunity (D. D'Ambrosio and F. Sinigaglia, eds.). Humana Press, Totowa, NJ. Methods in Molecular Biology 239:91-104.

  113. Devreotes, P.N. and Janetopoulos, C. 2003. Eukaryotic Chemotaxis: Distinctions between directional sensing and polarization. J. Biol. Chem. 278, 20445-20448. DOI:10.1074/jbc.r300010200

  114. Huang, E., Iijima, M., Parent, C.A., Funamoto, S., Firtel, R., and Devreotes, P.N. 2003. Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol. Bio. Cell 14, 1913-1922. DOI:10.1091/mbc.e02-10-0703

  115. Gilman, A.G., Devreotes, P.N., et al. 2002. Overview of the Alliance for Cellular Signaling. Nature 420, 703-706. DOI:10.1038/nature01304

  116. Pergolizzi, B., Peracino, B., Silverman, J., Ceccarelli, A., Noegel, A., Devreotes, P.N., and Bozzaro, S. 2002. Temperature-sensitive inhibition of development in Dictyostelium due to a point mutation in the piaA gene. Dev. Biol. 251, 18-27. DOI:10.1006/dbio.2002.0809

  117. Iijima, M., Huang, E., and Devreotes, P.N. 2002. Temporal and spatial regulation of chemotaxis. Dev. Cell 3, 469-478. DOI:10.1016/s1534-5807(02)00292-7

  118. Dormann, D., Weijer, G., Parent, C.A., Devreotes, P.N., and Weijer, C.J. 2002. Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr. Bio. 12, 1178-1188. DOI:10.1016/s0960-9822(02)00950-8

  119. Zhang, N., Long, Y., and Devreotes, P.N. 2002. Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in Dictyostelium. Dev. Bio. 248, 1-12. DOI:10.1006/dbio.2002.0715

  120. Iijima, M. and Devreotes, P. N. 2002. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610 (Cover). DOI:10.1016/s0092-8674(02)00745-6

  121. Janetopoulos, C. and Devreotes, P.N. 2002. Monitoring receptor-mediated activation of heterotrimeric G-proteins by fluorescence resonance energy transfer. Methods for the Study of Receptor-Receptor Interactions. (Yogesh C. Patel, ed.), Academic Press, San Diego, CA. Methods 27, 366-373. DOI:10.1016/s1046-2023(02)00095-6

  122. Zhao, M., Jin, T., McCaig, C., Forrester, J., and Devreotes, P.N. 2002. Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis. J. Cell Bio. 157(6), 921-927. DOI:10.1083/jcb.200112070

  123. Bankir, L., Ahloulay, M., Devreotes, P.N., and Parent, C.A. 2002. Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? Am J Physiol Renal Physiol. 282(3):F376-92. Review. DOI:10.1152/ajprenal.00202.2001

  124. Ueda, M., Sako, Y., Tanaka, T., Devreotes, P., and Yanagida, T. 2001. Single molecule analysis of chemotactic signaling in Dictyostelium cells. Science, 294(5543), 864-7. DOI:10.1126/science.1063951

  125. Parent, C., Borleis, J., and Devreotes, P.N. 2002. Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains. J. Biol. Chem. 277(2), 1354-1360. DOI:10.1074/jbc.m106430200

  126. Zhang, N, Long, Y. and Devreotes, P.N. 2001. Gγ in Dictyostelium:  Its role in localization of Gβγ to the membrane is required for chemotaxis in shallow gradients. Mol Bio Cell. 12(10), 3204-13. DOI:10.1091/mbc.12.10.3204

  127. Dormann, D., Kim, J-Y., Devreotes, P.N., and Weijer, C.J. 2001. cAMP receptor affinity controls wave dynamics, geometry and morphogenesis in Dictyostelium. J Cell Science 114, 2513-2523. DOI:10.1242/jcs.114.13.2513

  128. Verkerke-van Wijk, I., Fukuzawa, M., Devreotes, P.N., and Schaap, P. 2001. Adenylyl cyclase A expression is tip-specific in Dictyostelium slugs and directs StatA nuclear translocation and CudA gene expression. Dev. Biol. 234(1), 151-60. DOI:10.1006/dbio.2001.0232

  129. van Es, S., Weenings, K.E., and Devreotes, P.N. 2001. The protein kinase YakA regulates G-protein-linked signaling responses during growth and development of Dictyostelium. J Biol Chem, 276(33), 30761-30765. DOI:10.1074/jbc.m103365200

  130. Weiner, O.D., Servant, G., Parent, C.A., Devreotes, P.N., and Bourne, H.R. 2000. Cell polarity in response to chemoattractants, in Cell polarity (Drubin, D.G., ed). Frontiers in Molecular Biology (B.D. Hames and D.M. Glover, eds.) Oxford University Press, pp. 201-239.

  131. Briscoe, C., Moniakis, J., Kim, J-Y., Brown, J., Hereld, D., Devreotes, P.N., and Firtel, R. 2001. The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation. Dev. Biol., 233, 225-236. DOI:10.1006/dbio.2001.0217

  132. Janetopoulos, C., Jin, T. and Devreotes, P.N. 2001. Receptor mediated activation of heterotrimeric G-proteins in living cells. Science, 291, 2408-2411. 10.1126/science.1055835

  133. van Es, S., Wessels, D., Soll, D., Borleis, J., and Devreotes, P.N. 2001 Tortoise, a novel mitochondrial protein, is required for directional responses of dictyostelium in chemotactic gradients. J. Cell Biol., 152(3), 621-632. (PDF Version)

  134. Patel, H., Guo, K., Parent, C., Gross, J., Devreotes, P.N., Weijer, C.J. 2000. A temperature-sensitive adenylyl cyclase mutant of Dictyostelium. EMBO J., 19, 2247-56. DOI:10.1093/emboj/19.10.2247

  135. Garcia, M.X., Foote, C., van Es, S., Devreotes, P.N., Alexander, S., Alexander, H. 2000. Differential developmental expression and cell type specificity of dictyostelium catalases and their response to oxidative stress and UV-light. Biochim Biophys Acta., 1492, 295-310. DOI:10.1016/s0167-4781(00)00063-4

  136. Jin, T., Zhang, N., Long, Y., Parent, C., and Devreotes, P.N. 2000. Localization of the G protein betagamma complex in living cells during chemotaxis. Science, 287, 1034-1036. DOI:10.1126/science.287.5455.1034

  137. Devreotes, P. N. and International D. discoideum Organizing Committee. 1999. "D. discoideum: Model System in Motion". Promotional Web Site for Dictyostelium .

  138. Parent, C., Xiao, Z., Zhang, N., and Devreotes, P. N. 1999. "Chemotaxis in Eucaryotic Cell" in GFP in Motion (CD edited by Beat Ludin).

  139. Parent, C. and Devreotes, P.N. 1999. A Cell's Sense of Direction. Science, 284, 765-770. DOI:10.1126/science.284.5415.765

  140. van Es, S. and Devreotes, P.N. 1999. Molecular basis of localized signal responses during chemotaxis in amoebae and leukocytes. Cell. Mol. Life Sci., 55, 1341-1351. DOI:10.1007/s000180050374

  141. Vithalani, K.K., Parent, C.A., Thorn, E.M., Penn, M., Larochelle, D.A., Devreotes, P.N., and De Lozanne, A. 1998. Identification of darlin, a Dictyostelium protein with armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells. Mol. Biol. Cell, 9, 3095-3106. DOI:10.1091/mbc.9.11.3095

  142. Xiao, Z., Yao, Y., Long, Y. and Devreotes, P.N. 1999. Desensitization of G-protein-coupled Receptor - agonist-induced phosphorylation of the chemottractant receptor for cAR1 lowers its intrinsic affinity for cAMP. J. Biol. Chem, 274, 1440-1448. DOI:10.1074/jbc.274.3.1440

  143. Parent, C., Blacklock, B., Froelich, W., Murphy, D. and Devreotes, P.N. 1998. G protein signaling events are activated at the leading edge of chemotactic cells. Cell, 95, 81-91. DOI:10.1016/s0092-8674(00)81784-5

  144. Jin, T., Amzel, M., Devreotes, P.N. and Wu, C 1998. Selection of Gß subunits with point mutations that fail to activate specific signaling pathways in vivo: dissecting cellular responses mediated by a heterotrimeric G-protein in Dictyostelium discoideum. Mol. Biol. Cell. 9, 2949-2961. DOI:10.1091/mbc.9.10.2949

  145. Verkerke-Van Wijk, I., Kim, J-Y., Brandt, R., Devreotes, P.N. and Schaap, P. 1998. Functional promiscuity of gene regulation by serpentine receptors in Dictyostelium discoideum. Mol. Cell. Biol. 18, 5744-5749. DOI:10.1128/mcb.18.10.5744

  146. Peracino, B., Borleis, J., Jin, T., Westphal, M., Schwartz, J-M., Wu, L., Bracco, E., Gerisch, G., Devreotes, P.N., and Bozarro, S. 1998. G protein ß-subunit-null mutants are impaired in phagocytosis and chemotaxis due to inappropriate regulation of the actin cytoskeleton. J. Cell Biol., 141, 1529-1537. DOI:10.1083/jcb.141.7.1529

  147. Jin, T., Soede, R., Liu, J., Kimmel, A., Devreotes, P.N. and Schaap, P. 1998. Temperature-sensitive Gß discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors. EMBO J., 17, 5076-5084. DOI:10.1093/emboj/17.17.5076

  148. Kim, J-Y., Borleis, J.A. and Devreotes, P.N. 1998. Switching of chemoattractant receptors programs development and morphogenesis in Dictyostelium: Receptor subtypes activate common responses at different agonist concentrations. Develop. Biol., 197, 117-128. DOI:10.1006/dbio.1998.8882

  149. Mann, K.O., Brown, J.M., Briscoe, C., Parent, C., Pitt, G., Devreotes, P.N., and Firtel, R.A. 1997. Role of cAMP-dpendent potein knase in controlling aggregation and postaggregative development in Dictyostelium. Develop. Biol., 183, 208-221. DOI:10.1006/dbio.1996.8499

  150. Chen, M.-Y., Long, Y. and Devreotes, P.N. 1997. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the twelve transmembrane domain adenylyl cyclase in Dictyostelium. Genes and Development 11, 3218-3231. DOI:10.1101/gad.11.23.3218

  151. Xiao, Z., Zhang, N., Murphy, D.B. and Devreotes, P.N. 1997. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistant stimulation. J. Cell Biol. 139, 365-374. DOI:10.1083/jcb.139.2.365

  152. Kim, J-Y., Soede, R.D.M., Schaap, P., Valkema, R., Borleis, J.A., Van Haastert, P.J.M., Devreotes, P.N. and Hereld, D. 1997. Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses. J. Biol. Chem. 272, 27313-27318. DOI:10.1074/jbc.272.43.27313

  153. Zigmond, S.H., Joyce, M., Borleis, J., Bokoch, G.M. and Devreotes, P. 1997. Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. J. Cell Biol. 138, 363-374. DOI:10.1083/jcb.138.2.363

  154. Aubry, L., Maeda, M., Insall, R., Devreotes, P.N. and Firtel, R.A. 1997. The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function. J. Biol. Chem. 272, 3883-3886. DOI:10.1074/jbc.272.7.3883

  155. Kim, J-Y., Caterina, M.J., Milne, J.L.S., Lin, K.C., Borleis, J.A. and Devreotes, P.N. 1997. Random mutagenesis of the chemoattractant receptor, cAR1 of Dictyostelium: Mutant classes that cause discrete shifts in agonist affinity and lock the receptor in a novel activational intermediate. J. Biol. Chem. 272, 2060-2068. DOI:10.1074/jbc.272.4.2060

  156. Milne, J.L.S., Caterina, M.J. and Devreotes, P.N. 1997. Random mutagenesis of the cAMP chemoattractant receptor, cAR1, of Dictyostelium: Evidence for multiple states of activation. J. Biol. Chem. 272, 2069-2076. DOI:10.1074/jbc.272.4.2069

  157. Xiao, Z. and Devreotes, P.N. 1997. Identification of detergent-resistant plasma membrane microdomains in Dictyostelium: Enrichment of signal transduction proteins. Mol. Biol. Cell, 8, 855-869. DOI:10.1091/mbc.8.5.855

  158. van Es, S., Virdy, K.J., Pitt, G.S., Meima, M., Sands, T.W., Devreotes, P.N., Cotter, D.A., Schaap, P. 1996. Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores. J Biol Chem 271(39):23623-5. DOI:10.1074/jbc.271.39.23623

  159. Parent, C. and Devreotes, P.N. 1996. Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators. J. Biol. Chem. 271, 18333-18336. DOI:10.1074/jbc.271.31.18333

  160. Kim, J-Y., Haastert, P.V., and Devreotes, P. 1996. Social senses: G-protein coupled receptor signaling pathways in Dictyostelium discoideum. Chemistry and Biology 3, 239-243. (COVER). DOI:10.1016/s1074-5521(96)90103-9

  161. Maeda M., Aubry L., Insall R., Gaskins C., Devreotes P.N. and Firtel R.A. 1996. Role of heterotrimeric G proteins Receptor mediated activation of a MAPK: Role of G proteins. J. Biol. Chem. 271, 3351-3354. DOI:10.1074/jbc.271.7.3351

  162. Insall R., Borleis J. and Devreotes P.N. 1996. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Current Biology 6, 719-729. (COVER). DOI:10.1016/s0960-9822(09)00453-9

  163. Milne, J.L.S., Kim, J-Y. and Devreotes, P.N. 1996. Chemoattractant receptor signaling: G protein-dependent and -independent pathways. In: Signal Transduction in Health and Disease (J. Corbin and S. Francis, eds.), Raven Press.

  164. Parent, C.A. and Devreotes, P.N. 1996. Molecular genetics of signal transduction in Dictyostelium. Annu. Rev. Biochem. 65, 411-440. DOI:10.1146/annurev.bi.65.070196.002211

  165. Chen, M.-Y., Insall, R.H. and Devreotes, P.N. 1996. Signaling through chemoattractant receptors in Dictyostelium. TIGS 12, 52-57. (COVER). DOI:10.1016/0168-9525(96)81400-4

  166. Parent, C.A. and Devreotes, P.N. 1995. Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis. J. Biol. Chem. 270, 22693-22696. DOI:10.1074/jbc.270.39.22693

  167. Caterina, M., Devreotes, P.N., Borleis, J. and Hereld, D. 1995. Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G protein-coupled chemoattractant receptor from Dictyostelium. J. Biol. Chem. 270, 8667-8672. DOI:10.1074/jbc.270.15.8667

  168. Wu, L., Valkema, R., Van Haastert, P. J. M. and Devreotes, P. N. 1995. The G-protein ß-subunit is essential for multiple responses to chemoattractants in Dictyostelium. J. Cell Biol. 129, 1667-1675. DOI:10.1083/jcb.129.6.1667

  169. Lilly, P. J. and Devreotes, P. N. 1995. Chemoattractant and GTP?S mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes. J. Cell Biol. 129, 1659-1665. DOI:10.1083/jcb.129.6.1659

  170. Parent, C. and Devreotes, P.N. 1995. Molecular dissection of G protein-mediated signal transduction using random mutagenesis in Dictyostelium. Methods in Molecular Genetics (K.W. Adolph, ed.), Academic Press, Orlando, FL, pp. 3-15 (COVER).

  171. Milne, J.L.S., Wu, L., Caterina, M.J. and Devreotes, P.N. 1995. Seven helix cAMP receptors stimulate Ca2+ entry in the absence of functional G proteins in Dictyostelium. J. Biol. Chem. 270, 5926-5931. DOI:10.1074/jbc.270.11.5926

  172. Caterina, M., Hereld, D. and Devreotes, P.N. 1995. Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues. J. Biol. Chem. 270, 4418-4423. DOI:10.1074/jbc.270.9.4418

  173. Kim, J-Y and Devreotes, P.N. 1994. Random chimeragenesis of G-protein coupled receptors: mapping the affinity of the cAMP chemoattractant receptors in Dictyostelium. J. Biol. Chem. 269, 28724-28731. (https://www.jbc.org/article/S0021-9258(19)61965-4/pdf)

  174. Mann, S.K.O., Devreotes, P.N., Eliott, S., Jermyn, K., Kuspa, A., Fechheimer, M., Furukawa, R., Parent, C.A., Segall, J., Shaulsky, G., Vardy, P.H., Williams, J., Williams, K.L. and Firtel, R.A. 1994. Cell biological, molecular genetic, and biochemical methods to examine Dictyostelium. In: Cell Biology: A Laboratory Handbook, Vol. 1 (J.E. Celis, ed.) Academic Press, San Diego, pp. 412-451.

  175. Chen, M.-Y., Devreotes, P.N. and Gundersen, R.E. 1994. Serine-113 is the site of receptor-mediated phosphorylation of the Dictyostelium G protein a-subunit, Ga2. J. Biol. Chem. 269, 20925-20930. DOI:10.1016/S0021-9258(17)31910-5

  176. Soede, R.D.M., Insall, R.H., Devreotes, P.N. and Schaap, P. 1994. Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two, subtypes of early cAMP receptors (cARs). Evidence of involvement of cAR1 in aggregative gene expression. Development 120, 1997-2002. DOI:10.1242/dev.120.7.1997

  177. Insall, R., Kuspa, A., Lilly, P.J., Shaulsky, G., Levin, L.R., Loomis, W.F. and Devreotes, P.N. 1994. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 126, 1537-1545. DOI:10.1083/jcb.126.6.1537

  178. Insall, R.H., Soede, R.D.M., Schaap, P. and Devreotes, P.N. 1994. Two cAMP receptors activate common signalling pathways in Dictyostelium. Molec. Biol. of the Cell 5, 703-711. DOI:10.1091/mbc.5.6.703

  179. Wu, L., Gaskins, C., Zhou, K., Firtel, R.A. and Devreotes, P.N. 1994. Cloning and targeted mutations of Ga7 and Ga8, two developmentally regulated G protein a-subunit genes in Dictyostelium. Mol. Biol. of the Cell 5, 691-702. DOI:10.1091/mbc.5.6.691

  180. Lilly, P. and Devreotes, P.N. 1994. Identification of CRAC, a cytosolic protein required for guanine nucleotide stimulation of adenylyl cyclase in Dictyostelium. J. Biol. Chem. 269, 14123-14129. DOI:10.1016/S0021-9258(17)36763-7

  181. Hereld, D., Vaughan, R., Kim, J-Y., Borleis, J. and Devreotes, P. 1994. Localization of ligand-induced phosphorylation sites to serine clusters in the C-terminal domain of the Dictyostelium cAMP receptor, cAR1. J. Biol. Chem. 269, 7036-7044. DOI:10.1016/S0021-9258(17)37479-3

  182. Devreotes, P.N. 1994. G-protein linked signaling pathways control the developmental program of Dictyostelium. Neuron 12, 1-20 (Minireview). DOI:10.1016/0896-6273(94)90267-4

  183. Caterina, M.J., Milne, J.L.S. and Devreotes, P.N. 1994. Mutation of the third intracellular loop of the cAMP receptor, cAR1, of Dictyostelium yields mutants impaired in multiple signaling pathways. J. Biol. Chem. 269, 1523-1532. DOI:10.1016/S0021-9258(17)42288-5

  184. Pitt, G.S., Brandt, R., Lin, K.C., Devreotes, P.N. and Schaap, P. 1993. Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). Genes & Development 7, 2172-2180. DOI:10.1101/gad.7.11.2172

  185. Lilly, P., Wu, L., Welker, D.L. and Devreotes, P.N. 1993. A G-protein ß-subunit is essential for Dictyostelium development. Genes & Development 7, 986-995. DOI:10.1101/gad.7.6.986

  186. Milne, J. and Devreotes, P.N. 1993. The surface cyclic AMP receptors, cAR1, cAR2, and cAR3, promote Ca2+ influx in Dictyostelium discoideum by a Ga2-independent mechanism. Mol. Biol. of the Cell 4, 283-292. DOI:10.1091/mbc.4.3.283

  187. Johnson, R., Saxe, C.L. III, Gollop, Kimmel, A.R. and Devreotes, P.N. 1993. Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development. Genes & Development 7, 273-282. (PDF Version)

  188. Saxe, C.L. III, Ginsberg, G.T., Louis, J.M., Johnson, R., Devreotes, P.N. and Kimmel, A.R. 1993. cAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum. Genes & Development 7, 262-272. (COVER). (PDF Version)

  189. Van Haastert, P.J.M. and Devreotes, P.N. 1993. Biochemistry and genetics of sensory transduction in Dictyostelium. In: Signal Transduction: Prokaryotic and Simple Eukaryotic Systems (J. Kurjan and B.L. Taylor, eds.), Academic Press (Review), Orlando, FL., pp. 329-352.

  190. Wu, L., Gaskins, C., Gundersen, R., Hadwiger, J.A., Johnson, R.L., Pitt, G.S., Firtel, R.A. and Devreotes, P.N. 1993. Signal transduction by G-proteins in Dictyostelium discoideum. In: Handbook of Experimental Pharmacology, "GTPases in Biology II" (B. Dickey and L. Birnbaumer, eds.), Vol. 108, Springer-Verlag, pp. 335-349. (PDF Version)

  191. Johnson, R.L., Gundersen, R., Hereld, D., Pitt, G.S., Tugendreich, S., Saxe, C.L., Kimmel, A.R. and Devreotes, P.N. 1992. G-protein-linked signaling pathways mediate development in Dictyostelium. In: The Cell Surface, Vol. 57, Cold Spring Harbor Symp., Cold Spring Harbor Press, pp. 169-176.

  192. Pupillo, M., Insall, R., Pitt, G.S. and Devreotes, P.N. 1992. Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. Molec. Biol. of the Cell 3, 1229-1234. (PDF Version)

  193. Hereld, D., and Devreotes, P.N. 1992. The cAMP receptor family of Dictyostelium. In: Molecular Biology of Receptors and Transporters: Receptors (M. Friedlander and M. Mueckler, eds.), Vol.137B of International Review of Cytology, Academic Press, Orlando, FL, pp. 35-47.

  194. Van Haastert, P.J.M., Wang, M., Bominaar, A.A., Devreotes, P.N. and Schaap, P. 1992. cAMP-induced desensitization of surface cAMP receptors in Dictyostelium: Different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor, and reduction of receptor mRNA levels. Molec. Biol. of the Cell 3, 603-612. (PDF Version)

  195. Pitt, G.S., Milona, N., Borleis, J., Lin, K.C., Reed, R.R. and Devreotes, P.N. 1992. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyosteilum development. Cell 69, 305-315. (PDF Version)

  196. Johnson, R.L., Van Haastert, P.J.M., Kimmel, A.R., Saxe, C.L. III, Jastorff, B. and Devreotes, P.N. 1992. The cyclic nucleotide specificity of three cAMP receptors in Dictyostelium. J. Biol. Chem. 267, 4600-4607. (PDF Version)

  197. Wu, L. and Devreotes, P.N. 1991. Dictyostelium transiently expresses eight distinct G-protein a-subunits during its developmental program. Biochem. Biophys. Res. Commun. 179, 1141-1147.

  198. Caterina, M.J. and Devreotes, P.N. 1991. Molecular insights into eucaryotic chemotaxis. FASEB J. 5, 3078-3085. (PDF Version)

  199. Johnson, R.L., Vaughan, R.A., Caterina, M.J., Van Haastert, P.J.M. and Devreotes, P.N. 1991. Overexpression of the cAMP receptor 1 in growing Dictyostelium cells. Biochemistry 30, 6982-6986. (PDF Version)

  200. Sun, T.J. and Devreotes, P.N. 1991. Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium. Genes & Development 5, 572-582. (PDF Version)

  201. Saxe, C.L., Johnson, R., Devreotes, P.N. and Kimmel, A.R. 1991. Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum. Developmental Genetics 12, 6-13.

  202. Saxe, III, C.L., Johnson, R.L., Devreotes, P.N. and Kimmel, A.R. 1991. Expression of a cAMP receptor gene of Dictyostelium and evidence for a multigene family. Genes & Development 5, 1-8. (PDF Version)

  203. Pitt, G.S., Gundersen, R.E., Lilly, P.J., Pupillo, M.B., Vaughan, R.A. and Devreotes, P.N. 1990. G protein-linked signal transduction in aggregating Dictyostelium. J. Gen. Physiology, Chap. 10, pp. 125-131.

  204. Pitt, G.S., Gundersen, R.E. and Devreotes, P.N. 1990. Mechanisms of excitation and adaptation in Dictyostelium. Seminars in Cell Biology 1, 99-104.

  205. Sun, T.J., Van Haastert, P.J.M. and Devreotes, P.N. 1990. Surface cAMP receptors mediate multiple responses during development in Dictyostelium: Evidenced by antisense mutagenesis. J. Cell Biol. 110, 1549-1554. (PDF Version)

  206. Gundersen, R.E. and Devreotes, P.N. 1990. In vivo receptor-mediated phosphorylation of a G protein in Dictyostelium. Science 248, 591-593.

  207. Firtel, R., Van Haastert, P., Kimmel, A. and Devreotes, P. 1989. G-protein linked signal transducing pathways in development: Dictyostelium as an experimental system. Cell (Minireview) 58, 235-239.

  208. Vaughan, R., Johnson, R., Caterina, M. and Devreotes, P. 1989. Adaptation of chemoattractant elicited responses in Dictyostelium discoideum. NATO Conference on Sensing and Response, The Netherlands. In: Molecular Mechanisms of Desensitization to Signal Molecules (T.M. Konijn, et al., eds.) Springer-Verlag, Berlin, pp. 23-36.

  209. Johnson, R.L., Gundersen, R., Lilly, P., Pitt, G., Pupillo, M., Sun, T.J., Vaughan, R.A. and Devreotes, P.N. 1989. G-protein-linked signal transduction systems control development in Dictyostelium. British Society of Developmental Biology, St. Andrews, Scotland. Development (Supplement) 107, 75-80.

  210. Devreotes, P. 1989. Cell-cell interactions in Dictyostelium development. TIGS 5, 242-245.

  211. Devreotes, P. 1989. Dictyostelium discoideum: A model system for cell-cell interactions in development. Science 245, 1054-1058.

  212. Pupillo, M., Kumagai, A., Pitt, G.S., Firtel, R.A. and Devreotes, P.N. 1989. Multiple a-subunits of guanine nucleotide-binding proteins in Dictyostelium. Proc. Natl. Acad. Sci. USA 86, 4892-4896. (PDF Version)

  213. Kumagai, A., Pupillo, M., Gundersen, R., Miaki-Lye, R., Devreotes, P. and Firtel, R. 1989. Regulation and function of Ga protein subunits in Dictyostelium. Cell 57, 265-275 (COVER). (PDF Version)

  214. Gundersen, R.E., Johnson, R., Lilly, P., Pitt, G., Pupillo, M., Sun, T., Vaughan, R. and Devreotes, P.N. 1989. Reversible phosphorylation of G-protein-coupled receptors controls cAMP oscillations in Dictyostelium. In: Cell to Cell Signalling: From Experiments to Theoretical Models. (A. Goldbeter, ed.) Academic Press, London, pp. 477-486.

  215. Lilly, P., Klein, P., Theibert, A., Vaughan, R., Pupillo, M., Saxe, C., Kimmel, A. and Devreotes, P. 1988. Receptor G-protein interactions in the development of Dictyostelium. Bot. Acta 101, 123-127.

  216. Pitt, G.S. and Devreotes, P.N. 1988. A simple BASIC program allows the rapid entry of DNA nucleotide sequences into personal computers. BioTechniques 6, 122-123.

  217. Snaar-Jagalska, B.E., Devreotes, P.N. and Van Haastert, P.J.M. 1988. Ligand-induced modification of a surface cAMP receptor of Dictyostelium discoideum does not require its occupancy. J. Biol. Chem. 263, 897-901. (PDF Version)

  218. Wang, M., Van Haastert, P.J.M., Devreotes, P. and Schaap, P. 1988. Localization of chemoattractant receptors on Dictyostelium discoideum cells during aggregation and down-regulation. Develop. Biol. 128, 72-77.

  219. Devreotes, P.N. and Zigmond, S.H. 1988. Chemotaxis in eucaryotic cells: A focus on leukocytes and Dictyostelium. Ann. Rev. Cell Biol. 4, 649-686. (PDF Version)

  220. Kumagai, A., Mann, S., Pupillo, M., Pitt, G., Devreotes, P. and Firtel, R. 1988. A molecular analysis of G-proteins and control of early gene expression by the cell surface cAMP receptor in Dictyostelium. In: Molecular Biology of Signal Transduction, Cold Spring Harbor Symposium, Vol. 53, pp. 675-685.

  221. Pupillo, M., Klein, P., Vaughan, R., Pitt, G., Lilly, P., Sun, T., Devreotes, P., Kumagai, A. and Firtel, R. 1988. cAMP receptor and G-protein interactions control development in Dictyostelium. In: Molecular Biology of Signal Transduction, Cold Spring Harbor Symposium, Vol. 53, pp. 657-665.

  222. Vaughan, R. and Devreotes, P. 1988. Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum. J. Biol. Chem. 263, 14538-14543. (PDF Version)

  223. Saxe, C.L., Klein, P., Sun, T.J., Kimmel, A. and Devreotes, P. 1988. Structure and expression of the cAMP cell-surface receptor. Develop. Gen. 9, 227-233.

  224. Klein, P.S., Sun, T.L., Saxe, C.L. III, Kimmel, A.R., Johnson, R.L. and Devreotes, P.N. 1988. A chemoattractant receptor controls development in Dictyostelium discoideum. Science 241, 1467-1472. (PDF Version)

  225. Berlot, C.H., Devreotes, P.N. and Spudich, J.A. 1988. Role of myosin phosphorylation in Dictyostelium chemotaxis. In: Signal Transduction in Cytoplasmic Organization and Cell Motility (Proceedings UCLA Conference, Lake Tahoe, CA) Alan R. Liss, Inc., pp. 287-292.

  226. Klein, P., Theibert, A. and Devreotes, P. 1988. Identification and ligand-induced modification of the cAMP receptor in Dictyostelium. Methods in Enzymology 159, 267-278.

  227. Berlot, C., Devreotes, P. and Spudich, J. 1987. Chemoattractant-elicited increases in Dictyostelium myosin phosphorylation are due to changes in myosin localization and increases in kinase activity. J. Biol. Chem. 262, 3918-3926. (PDF Version)

  228. Vaughan, R., Pupillo, M., Theibert, A., Klein, P. and Devreotes, P. 1987. Surface receptor mediated activation and adaptation of adenylate cyclase in Dictyostelium. NATO Workshop on Receptor-Mediated Desensitization. In: Molecular Mechanisms of Desensitization to Signal Molecules, (T.M. Konijn, P.J.M. Van Haas, H. Van der Staue, H. Van der Wel, and M.D. Houslay, eds.) Springer-Verlag, Berlin, Series H: Cell Biology, Vol. 6, pp. 15-24.

  229. Klein, P., Vaughan, R., Borleis, J. and Devreotes, P. 1987. The surface cyclic AMP receptor in Dictyostelium. J. Biol. Chem. 262, 358-364. (PDF Version)

  230. Klein, P., Knox, B., Borleis, J. and Devreotes, P. 1987. Purification of the surface cAMP receptor in Dictyostelium. J. Biol. Chem. 262, 352-357.­ (PDF Version)

  231. Devreotes, P., Fontana, D., Klein, P., Sherring, J. and Theibert, A. 1987. Transmembrane signalling in Dictyostelium. Methods in Cell Biology 28, 299-331.

  232. Reymond, C., Gomer, R., Nellen, W., Theibert, A., Devreotes, P. and Firtel, R. 1986. Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants. Nature 323, 340-343.

  233. Theibert, A. and Devreotes, P. 1986. Surface receptor-mediated activation of adenylate cyclase in Dictyostelium: Regulation by guanine nucleotides in wild-type cells and aggregation deficient mutants. J. Biol. Chem. 261, 15121-15125. (PDF Version)

  234. Knox, B., Devreotes, P., Goldbeter, A. and Segel, L. 1986. A molecular mechanism for sensory adaptation based on ligand-induced receptor modification. Proc. Natl. Acad. Sci. USA 83, 2345-2349. (PDF Version)

  235. Theibert, A., Fontana, D., Wong, T-Y. and Devreotes, P. 1986. Cell-cell interactions in the development of Dictyostelium. The American Zoologist 26, 549-551. (PDF Version)

  236. Segel, L., Goldbeter, A., Devreotes, P. and Knox, B. 1986. A Mechanism for Exact Sensory Adaptation Based on Receptor Modification. In: Sensing and Response in Microorganisms (Proceeding of 13th Annual Aharon Katzir-Katchalsky Symposium, The Weizmann Institute, Rehovoth, Israel, March 17-22, 1985). (PDF Version)

  237. Berlot, C., Spudich, J. and Devreotes, P. 1985. Chemoattractant-elicited increases in myosin phosphorylation in Dictyostelium. Cell 43, 307-314.

  238. Theibert, A., Palmisano, M., Jastorff, B. and Devreotes, P. 1986. The specificity of the cAMP receptor mediating activation of adenylate cyclases in Dictyostelium discoideum. Develop. Biol. 114, 529-533.

  239. Segel, L., Goldbeter, A., Devreotes, P. and Knox, B. 1986. A mechanism for exact sensory adaptation based on receptor modification. J. Theor. Biol. 120, 151-179.

  240. Klein, P., Fontana, D., Knox, B., Theibert, A., and Devreotes, P. 1985. Cyclic AMP receptors controlling cell-cell interactions in the development of Dictyostelium. In: Molecular Biology of Development, Cold Spring Harbor Symposium on Quantitative Biology, Vol. 50, pp. 787-799.

  241. Devreotes, P. and Sherring, J. 1985. Kinetics and concentration dependence of reversible cAMP induced modification of the surface cAMP receptor in Dictyostelium. J. Biol. Chem. 260, 6378-6384. (PDF Version)

  242. Klein, P., Theibert, A., Fontana, D. and Devreotes, P. 1985. Identification and cyclic AMP-induced modification of the cyclic AMP receptor in Dictyostelium discoideum. J. Biol. Chem. 260, 1757-1764. (PDF Version)

  243. Chisholm, R., Fontana, D., Theibert, A., Lodish, H. and Devreotes, P. 1984. The development of Dictyostelium discoideum: Chemotaxis, cell-cell adhesion, and gene expression. In: Microbial Development (R. Losick and L. Shapiro, eds.) Cold Spring Harbor, NY, pp. 219-254. (PDF Version)

  244. Fontana, D., Wong, T-Y., Theibert, A. and Devreotes, P. 1984. Cell-cell interactions in the development of Dictyostelium. In: The Cell Surface in Development and Cancer (M.S. Steinberg, ed.) Plenum.

  245. Theibert, A., Klein, P. and Devreotes, P. 1984. Specific photoaffinity labeling of the cAMP surface receptor in Dictyostelium. J. Biol. Chem. 259, 12318-12321. (PDF Version)

  246. Theibert, A. and Devreotes, P. 1984. Adenosine and its derivatives inhibit the cyclic AMP signaling response in Dictyostelium. Develop. Biol. 106, 166-173.

  247. Fontana, D. and Devreotes, P. 1984. cAMP-stimulated adenylate cyclase activation in Dictyostelium is inhibited by agents acting at the cell surface. Develop. Biol. 106, 76-82.

  248. Theibert, A. and Devreotes, P.N. 1983. Cyclic 3',5'-AMP relay in Dictyostelium discoideum. VI. Adaptation is independent of activation of adenylate cyclase. J. Cell Biol. 97, 173-177. (PDF Version)

  249. Devreotes, P.N., Potel, M.J. and Mackay, S. 1983. Quantitative analysis of cAMP waves mediating aggregation in Dictyostelium discoideum. Develop. Biol. 96, 405-415.

  250. Devreotes, P.N. 1983. The effect of folic acid on cAMP elicited cAMP production in Dictyostelium discoideum. Develop. Biol. 95, 154-162.

  251. Devreotes, P.N. 1983. Cyclic nucleotides and cell-cell communication in Dictyostelium discoideum. Advances in Cyclic Nucleotide Research, Vol. 15, pp. 55-96.

  252. Devreotes, P.N. 1982. Chemotaxis. In: The Development of Dictyostelium discoideum (W.F. Loomis, ed.) Academic Press, San Diego, Chap. 4, pp. 117-168.

  253. Tomchik, K.J. and Devreotes, P.N. 1981. Cyclic AMP waves in Dictyostelium discoideum: A demonstration by isotope dilution fluorography. Science 212, 443-446. (COVER). (PDF Version)

  254. Dinauer, M.C., Steck, T.L. and Devreotes, P.N. 1980. Cyclic 3',5'-AMP relay in Dictyostelium discoideum. V. Adaptation of the cAMP signaling response during cAMP stimulation. J. Cell Biol. 86, 554-561. (PDF Version)

  255. Dinauer, M.C., Steck. T.L. and Devreotes, P.N. 1980. Cyclic 3',5'-AMP relay in Dictyostelium discoideum. IV. Recovery of the cAMP signaling response after adaptation to cAMP. J. Cell Biol. 86, 545-553. (PDF Version)

  256. Dinauer, M.C., Mackay, S.A. and Devreotes, P.N. 1980. Cyclic 3',5'-AMP relay in Dictyostelium discoideum. III. The relationship of cAMP synthesis and secretion during the cAMP signaling response. J. Cell Biol. 86, 537-544. (PDF Version)

  257. Devreotes, P. and Steck, T. 1979. Cyclic 3',5'-AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response. J. Cell Biol. 80, 300-309. (PDF Version)

  258. Devreotes, P.N., Derstine, P.L. and Steck, T.L. 1979. Cyclic 3',5'-AMP relay in Dictyostelium discoideum. I. A technique to monitor responses to controled stimuli. J. Cell Biol. 80, 291-299. (PDF Version)

  259. Fambrough, D.M., Card-Linden, D., Devreotes, P.N., Gardner, J.M. and Rotundo, R.L. 1979. On the regulation of the number and distribution of acetylcholine receptors in skeletal muscle. In: Nerve Cells, Transmitters and Behavior (R. Levi-Motaleni and C. Chagas, eds.). Elsevier Press.

  260. Devreotes, P.N. 1976. Biosynthesis and degradation of acetylcholine receptors in developing embryonic myotubes. Ph.D. Thesis, Johns Hopkins University.

  261. Fambrough, D.M., Devreotes, P.N., Gardner, J.M. and Card, D.J. 1979. The life history of acetylcholine receptors. In: Progress in Brain Research (The Cholinergic Synapse) (S. Tucek, ed.) 49, 325-334. (PDF Version)

  262. Fambrough, D.M. and Devreotes, P.N. 1978. Newly synthesized acetylcholine receptors are located in the Golgi. J. Cell Biol. 76, 237-244. (PDF Version)

  263. Devreotes, P.N., Gardner, J. and Fambrough, D.M. 1977. Kinetics of biosynthesis of acetylcholine receptors and subsequent incorporation into plasma membranes of cultured skeletal muscle. Cell 10, 365-373.

  264. Devreotes, P.N. Card, D.J., Tepperman, K.G. and Fambrough, D.M. 1977. Studies on the metabolism of acetylcholine receptors in skeletal muscles. In: Exploratory Concepts in Muscular Dystrophy III (I.P. Rowland, ed.).

  265. Fambrough, D.M. Devreotes, P.N., Card, D.J., Gardner, J. and Tepperman, K. 1977. Metabolism of acetylcholine receptors in skeletal muscle. National Cancer Institute Monograph 48, 277-294. (PDF Version)

  266. Fambrough, D.M., Devreotes, P.N. and Card, D.J. 1977. The synthesis and degradation of acetylcholine receptors. In: The Synapse (G.A. Cottrell, ed.) Blackie & Sons Ltd., Glasgow, pp. 203-237

  267. Devreotes, P.N. 1977. Acetylcholine. In: McGraw-Hill Encyclopedia of Science and Technology (D. Lapides, ed.).

  268. Devreotes, P.N. and Fambrough, D.M. 1976. Synthesis of acetylcholine receptors by cultured chick myotubes and denervated mouse extensor longus digiturum muscles. Proc. Natl. Acad. Sci., USA 73, 161-164. (PDF Version)

  269. Fambrough, D.M. and Devreotes, P.N. 1976. Development of chemical excitability in skeletal muscle. In: Biogenesis and Turnover of Membrane Molecules (J. Cook, ed.) Raven Press, NY.

  270. Devreotes, P.N. and Fambrough, D.M. 1976. Turnover of acetylcholine receptors in skeletal muscle. In: Cold Spring Harbor Symposium on Quantitative Biology XL, 40, 237-251.

  271. Devreotes, P.N. and Fambrough, D.M. 1975. Acetylcholine receptor turnover in membranes of developing muscle fibers. J. Cell Biol. 65, 335-358. (PDF Version)

  272. Fambrough, D.M. and Devreotes, P.N. 1975. Synthesis and degradation of acetylcholine receptors in cultured chick skeletal muscle. In: Exploratory Concepts in Muscular dystrophy II. (A.T. Milhorat, ed.) Excerpta Medica, Amsterdam, pp. 55-67.


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