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Which alterations in polarity signaling pathways result in oncogenesis? How do defects in cell migration transform normal cells to cancer cells? How do cancer cells differ from normal cells in terms of the spatiotemporal organization of signaling and cytoskeletal events? Do these organizational changes reprogram the energetics and metabolism of cancer cells? We are really interested in finding answers to these questions.
Zhan H, Pal DS, Borleis J, Janetopoulos C, Huang C-H, and Devreotes PN. 2024. Self-organizing glycolytic waves fuel cell migration and cancer progression. bioRxiv [Preprint]. DOI: 10.1101/2024.01.28.577603.
Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang C-H, and Devreotes PN. 2020. An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Dev Cell. 54(5):608-623.e5. DOI: 10.1016/j.devcel.2020.08.001.
Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, Ewald AJ, and Devreotes PN. 2020. Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. Proc Natl Acad Sci U S A. 117(8): 4158-4168. DOI: 10.1073/pnas.1917938117.