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How does the plasma membrane act as the hub of signal transduction during cell migration and polarity? How do different classes of membrane proteins dynamically compartmentalize into specific membrane regions? How is the symmetry breaking process initiated in plasma membrane? How do different lipid compositions and biophysical properties of membrane domains define the signaling state? How does the plasma membrane integrate information to encode templates for self-organization? Our research aims to address these questions.
Deng Y, Banerjee T, Pal DS, Banerjee P, Zhan H, Borleis J, Iglesias PA, Devreotes PN. 2024. PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration, bioRxiv [preprint]. DOI: 10.1101/2024.09.15.613115.
Banerjee T, Matsuoka S, Biswas D, Miao Y, Pal DS, Kamimura Y, Ueda M, Devreotes PN, and Iglesias PA. 2023. A dynamic partitioning mechanism polarizes membrane protein distribution. Nat Commun. 14:7909. DOI: 10.1038/s41467-023-43615-2.
Banerjee T, Biswas D*, Pal DS*, Miao Y, Iglesias PA, and Devreotes PN. 2022. Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration. Nat Cell Biol. 24, 1499–1515 (2022). DOI: 10.1101/2022.05.19.492577.
Li X*, Edwards M*, Swaney KF, Singh N, Bhattacharya S, Borleis J, Long Y, Iglesias PA, Chen J, and Devreotes PN. 2018. Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration. Proc Natl Acad Sci U S A 115(39), E9125-E9134. DOI: 10.1073/pnas.1809039115.
Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias P, Devreotes PN. 2017. Altering the threshold of an excitable signal transduction network changes cell migratory mode. Nat Cell Biol 19(4):329-340. DOI: 10.1038/ncb3495.