Members

Peter N. Devreotes, Ph.D.

Principal Investigator

Our group studies chemotactic cell migration, the ability to sense external gradients and respond directionally. This process plays a key role in normal physiology and we believe that knowledge of this fundamental process will also lead to new therapeutic strategies for inflammatory disease and metastasis. Studies in the amoeba Dictyostelium have shown that surface chemoattractant receptors and G-proteins are not significantly clustered at the front of the cell while downstream signaling events, such as PIP₃ accumulation, are sharply localized at the cell's leading edge. A few proteins have also been localized at the trailing edge. Many of these findings have been repeated in human and zebrafish neutrophils demonstrating the generality of the mechanisms.

Bedri Abubaker-Sharif

Graduate Student

Tatsat Banerjee

Graduate Student

Jane Borleis

Research Specialist

Yu Deng

Graduate Student

Chris Janetopoulos, Ph.D.

Visiting Scientist

Jonathan Kuhn, Ph.D.

Postdoc

Yiyan Lin

Graduate Student

Yu Long

Research Specialist

Suchitra Mitra, Ph.D.

Postdoc

Dhiman Pal, Ph.D.

Postdoc

Wei Qian

Research Specialist

Huiwang (David) Zhan, Ph.D.

Postdoc